TY - JOUR
T1 - TIME TO DEVELOP CHRONIC KIDNEY DISEASE IN AN ECUADORIAN TYPE 2 DIABETES MELLITUS COHORT: SURVIVAL ANALYSIS IN PRIMARY CARE
T2 - Survival analysis in primary care
AU - Carrasco-Tenezaca, Felipe
AU - Barrera-Guarderas, Francisco
AU - De la Torre-Cisneros, Katherine
AU - Medina-Escudero, Miguel
AU - Venegas-Baca, Oscar
N1 - Publisher Copyright:
© 2021 Elsevier Inc.
PY - 2021/12/22
Y1 - 2021/12/22
N2 - Chronic Kidney Disease (CKD) represents a high burden to health systems. However, the survival time for CKD in a Type 2 Diabetes Mellitus (T2DM) population is unknown. Aims: Determine the risk factors, survival time and the incidence rate of CKD in T2DM. Methods: Retrospective clinical cohort study (follow up 10 years). 513 patients with T2DM were included. Numerical variables were compared using the mean difference. Chi squared and odds ratios were calculated for categorical variables. Survival analysis was done through life tables and Kaplan-Meier. Results: The mean difference between the group that developed CKD and those who did not, was significant in: age, age at diagnosis of T2DM and years with T2DM. Risk factors for developing CKD were: the presence of hypertension, albuminuria, retinopathy, high triglycerides and high HbA1c. The incidence rate was 32.07 per 1000 person-years of follow-up and 207 (40.4%) of patients developed CKD during the study. The median for developing CKD was 20.52 years of disease with an increasing risk with time. Conclusions: Half of the patients with T2DM will develop CKD by the second decade of disease. Time, arterial hypertension, retinopathy, albuminuria and triglycerides are factors associated with CKD in patients with T2DM.
AB - Chronic Kidney Disease (CKD) represents a high burden to health systems. However, the survival time for CKD in a Type 2 Diabetes Mellitus (T2DM) population is unknown. Aims: Determine the risk factors, survival time and the incidence rate of CKD in T2DM. Methods: Retrospective clinical cohort study (follow up 10 years). 513 patients with T2DM were included. Numerical variables were compared using the mean difference. Chi squared and odds ratios were calculated for categorical variables. Survival analysis was done through life tables and Kaplan-Meier. Results: The mean difference between the group that developed CKD and those who did not, was significant in: age, age at diagnosis of T2DM and years with T2DM. Risk factors for developing CKD were: the presence of hypertension, albuminuria, retinopathy, high triglycerides and high HbA1c. The incidence rate was 32.07 per 1000 person-years of follow-up and 207 (40.4%) of patients developed CKD during the study. The median for developing CKD was 20.52 years of disease with an increasing risk with time. Conclusions: Half of the patients with T2DM will develop CKD by the second decade of disease. Time, arterial hypertension, retinopathy, albuminuria and triglycerides are factors associated with CKD in patients with T2DM.
KW - Diabetes complications
KW - Diabetic nephropathy
KW - Primary care
KW - Survival analysis
KW - Type 2 Diabetes Mellitus
UR - http://www.scopus.com/inward/record.url?scp=85121977611&partnerID=8YFLogxK
U2 - 10.1016/j.jdiacomp.2021.108108
DO - 10.1016/j.jdiacomp.2021.108108
M3 - Article
C2 - 34965908
AN - SCOPUS:85121977611
SN - 1056-8727
VL - 36
JO - Journal of Diabetes and its Complications
JF - Journal of Diabetes and its Complications
IS - 2
M1 - 108108
ER -