The role of ATP-binding cassette transporter genes in the metastatic process of epithelial thyroid carcinoma with aggressive behavior

Giovanna Revilla, Antonio Moral, Victoria Fuste, Enrique Lerma, Josep Julve, Joan Carles Escolà-Gil, Eugènia Mato, José Ignacio Pérez, Rosa Corcoy, Enma Veronica Paez Espinosa

Producción científica: Capítulo del libro/informe/acta de congresoCapítulorevisión exhaustiva

Resumen

There is a strong association between the increased expression of ATP-binding cassette (ABC) transporters, multidrug resistant tumors, and worse prognoses. This chapter summarizes the roles of ABCB1, ABCC1, and ABCG2 in the dedifferentiation, refractoriness, and epithelial-mesenchymal transition (EMT) processes in epithelial thyroid cancer (ETC). Although the molecular mechanisms involved in the EMT associated with resistant tumors remain poorly understood, the major inducers—HIF-1, NF-κB, TGF-β, Snail, SOX2, MSX, ZEB1, Twist, and Snail1—together with the PI3K/Akt, MAPK, Hedgehog, Wnt/β-catenin, Notch, and Hippo signaling pathways, have been identified as critical in the ETC malignancy process. Moreover, the tyrosine kinase inhibitors, used as therapeutic strategies in radioactive iodine I-131 (RAI) refractory thyroid carcinomas and aggressive tumors, are actively transported through these ABC transporters and can play a critical role in the chemoresistance of some ETC subtypes.

Idioma originalInglés
Título de la publicación alojadaUnraveling the Complexities of Metastasis
Subtítulo de la publicación alojadaTransition from a Segmented View to a Conceptual Continuum
EditorialElsevier
Páginas265-275
Número de páginas11
ISBN (versión digital)9780128217894
ISBN (versión impresa)9780128217900
DOI
EstadoPublicada - 1 ene. 2022

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