Significance of hepatitis b surface antigen, igm/igg core antibody and hepatitis b virus dna in blood donors

Título traducido de la contribución: Significación de los marcadores infecciosos para identificar portadores de hepatitis b en donantes de sangre

Rosa Chiriboga-Ponce, Gabriela Cueva-Tirira, Carolina Crespo-Proaño, Andrés González-Rodríguez, Pedro Pineda-Males, Mario J. Grijalva-Cobo

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

Resumen

Introduction: Identification of hepatitis B virus carriers in blood donors is imperative in order to avoid transmission of the disease via blood transfusion. Objective: To determine if blood donors with positive results for serological markers HBsAg and anti-HBc were hepatitis B virus DNA carriers. Methods: 12,745 samples were collected from six Ecuadorian blood banks and analyzed for HBsAg, anti-HBc and anti-HBs infectious markers by automated ELISA. All samples that tested positive for one, two or all three markers were analyzed with molecular techniques to determine the presence of viral DNA. Results: 27.5 % of the samples that were reactive for anti-HBc alone and 100 % of those with positive results for HbsAg and IgM/IgG anti-HBc were identified to contain hepatitis B virus DNA (p = 0.001). Conclusions: The selection of infection markers, as well as the detection methods define the results. Performing two serological and one molecular test is important in order to identify hepatitis B virus carriers and prevent its transmission.

Título traducido de la contribuciónSignificación de los marcadores infecciosos para identificar portadores de hepatitis b en donantes de sangre
Idioma originalInglés
Páginas (desde-hasta)35-40
Número de páginas6
PublicaciónGaceta Medica de Mexico
Volumen157
N.º1
DOI
EstadoPublicada - 2021

Nota bibliográfica

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© 2020 Academia Nacional de Medicina de México, A.C.. Published by Permanyer.

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