TY - JOUR
T1 - Self-Assessment of Disability in Parkinson's Disease
T2 - The MDS-UPDRS Part II Versus Clinician-Based Ratings
AU - Rodríguez-Blázquez, Carmen
AU - Alvarez, Mario
AU - Arakaki, Tomoko
AU - Campos Arillo, Víctor
AU - Chaná, Pedro
AU - Fernández, William
AU - Garretto, Nélida
AU - Martínez-Castrillo, Juan Carlos
AU - Rodríguez-Violante, Mayela
AU - Serrano-Dueñas, Marcos
AU - Ballesteros, Diego
AU - Rojo-Abuin, Jose Manuel
AU - Ray Chaudhuri, Kallol
AU - Merello, Marcelo
AU - Martínez-Martín, Pablo
N1 - Publisher Copyright:
© 2016 International Parkinson and Movement Disorder Society
PY - 2017/7/1
Y1 - 2017/7/1
N2 - Background: Parkinson's disease (PD) is characterized by motor and nonmotor symptoms that progress with time, causing disability. The performance of a disease-specific, self-applied tool for assessing disability, the MDS-UPDRS Part II, is tested against generic and rater-based rating scales. Methods: An international, cross-sectional, observational study was performed. Patients were assessed with the Hoehn and Yahr (HY) and five disability measures: MDS-UPDRS Part II, Schwab and England Scale (S&E), Clinical Impression of Severity Index-PD (CISI-PD) Disability item, Barthel Index (BI), and Rapid Assessment of Disability Scale (RADS). Data analysis included correlation coefficients, Mann-Whitney and Kruskal-Wallis tests, and intraclass-correlation coefficient for concordance. Results: The sample was composed of 451 patients, 55.2% men, with a mean age of 65.06 years (SD = 10.71). Disability rating scales correlated from |0.75| (CISI-PD Disability with BI) to 0.87 (MDS-UPDRS Part II with RADS). In general, MDS-UPDRS Part II showed high correlation coefficients with clinical variables and satisfactory concordance with the rest of disability measures, with ICC ranging from 0.83 (with BI) to 0.93 (with RADS). All disability rating scales showed statistical significant differences in the sample grouped by sex, age, disease duration, and severity level. Conclusions: The MDS-UPDRS Part II showed an appropriate performance to assess disability in PD, even better than some rater-based, generic or specific, scales applied in this study.
AB - Background: Parkinson's disease (PD) is characterized by motor and nonmotor symptoms that progress with time, causing disability. The performance of a disease-specific, self-applied tool for assessing disability, the MDS-UPDRS Part II, is tested against generic and rater-based rating scales. Methods: An international, cross-sectional, observational study was performed. Patients were assessed with the Hoehn and Yahr (HY) and five disability measures: MDS-UPDRS Part II, Schwab and England Scale (S&E), Clinical Impression of Severity Index-PD (CISI-PD) Disability item, Barthel Index (BI), and Rapid Assessment of Disability Scale (RADS). Data analysis included correlation coefficients, Mann-Whitney and Kruskal-Wallis tests, and intraclass-correlation coefficient for concordance. Results: The sample was composed of 451 patients, 55.2% men, with a mean age of 65.06 years (SD = 10.71). Disability rating scales correlated from |0.75| (CISI-PD Disability with BI) to 0.87 (MDS-UPDRS Part II with RADS). In general, MDS-UPDRS Part II showed high correlation coefficients with clinical variables and satisfactory concordance with the rest of disability measures, with ICC ranging from 0.83 (with BI) to 0.93 (with RADS). All disability rating scales showed statistical significant differences in the sample grouped by sex, age, disease duration, and severity level. Conclusions: The MDS-UPDRS Part II showed an appropriate performance to assess disability in PD, even better than some rater-based, generic or specific, scales applied in this study.
KW - MDS-UPDRS
KW - Parkinson's disease
KW - assessment
KW - disability
KW - rating scales
UR - http://www.scopus.com/inward/record.url?scp=85067370683&partnerID=8YFLogxK
U2 - 10.1002/mdc3.12462
DO - 10.1002/mdc3.12462
M3 - Article
AN - SCOPUS:85067370683
SN - 2330-1619
VL - 4
SP - 529
EP - 535
JO - Movement Disorders Clinical Practice
JF - Movement Disorders Clinical Practice
IS - 4
ER -