Regeneration of Sensory Hair Cells Requires Localized Interactions between the Notch and Wnt Pathways

Andrés Romero-Carvajal, Joaquín Navajas Acedo, Linjia Jiang, Agne Kozlovskaja-Gumbriene, Richard Alexander, Hua Li, Tatjana Piotrowski

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

79 Citas (Scopus)

Resumen

In vertebrates, mechano-electrical transduction of sound is accomplished by sensory hair cells. Whereas mammalian hair cells are not replaced when lost, in fish they constantly renew and regenerate after injury. In vivo tracking and cell fate analyses of all dividing cells during lateral line hair cell regeneration revealed that support and hair cell progenitors localize to distinct tissue compartments. Importantly, we find that the balance between self-renewal and differentiation in these compartments is controlled by spatially restricted Notch signaling and its inhibition of Wnt-induced proliferation. The ability to simultaneously study and manipulate individual cell behaviors and multiple pathways in vivo transforms the lateral line into a powerful paradigm to mechanistically dissect sensory organ regeneration. The striking similarities to other vertebrate stem cell compartments uniquely place zebrafish to help elucidate why mammals possess such low capacity to regenerate hair cells.

Idioma originalInglés
Páginas (desde-hasta)267-282
Número de páginas16
PublicaciónDevelopmental Cell
Volumen34
N.º3
DOI
EstadoPublicada - 10 ago. 2015
Publicado de forma externa

Nota bibliográfica

Publisher Copyright:
© 2015 Elsevier Inc.

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