Imaging collective cell migration and hair cell regeneration in the sensory lateral line

M. Venero Galanternik, J. Navajas Acedo, A. Romero-Carvajal, T. Piotrowski

Producción científica: Capítulo del libro/informe/acta de congresoContribución de conferenciarevisión exhaustiva

10 Citas (Scopus)

Resumen

The accessibility of the lateral line system and its amenability to long-term in vivo imaging transformed the developing lateral line into a powerful model system to study fundamental morphogenetic events, such as guided migration, proliferation, cell shape changes, organ formation, organ deposition, cell specification and differentiation. In addition, the lateral line is not only amenable to live imaging during migration stages but also during postembryonic events such as sensory organ tissue homeostasis and regeneration. The robust regenerative capabilities of the mature, mechanosensory lateral line hair cells, which are homologous to inner ear hair cells and the ease with which they can be imaged, have brought zebrafish into the spotlight as a model to develop tools to treat human deafness. In this chapter, we describe protocols for long-term in vivo confocal imaging of the developing and regenerating lateral line.

Idioma originalInglés
Título de la publicación alojadaThe Zebrafish Cellular and Developmental Biology, Part B Developmental Biology, 2016
EditoresLeonard I. Zon, Monte Westerfield, H. William Detrich
EditorialAcademic Press Inc.
Páginas211-256
Número de páginas46
ISBN (versión impresa)9780128050552
DOI
EstadoPublicada - 2016

Serie de la publicación

NombreMethods in Cell Biology
Volumen134
ISSN (versión impresa)0091-679X

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