Geohelminth infections: Impact on allergic diseases

Ana Lucia Moncayo, Philip John Cooper

Producción científica: Contribución a una revistaEncuesta cortarevisión exhaustiva

16 Citas (Scopus)


Geohelminth infections are highly prevalent infections with a worldwide distribution. Epidemiological studies have shown an inverse relationship between geohelminth infection and allergy leading to the suggestion that geohelminths protect against allergy. A causal association is supported by the findings of intervention studies in humans and experimental animal models. Geohelminths cause chronic infections during which an intimate host-parasite interaction develops permitting the parasite to survive but protecting the host from damaging inflammation. Geohelminth parasites modulate allergic inflammation directed against parasite antigens and the same mechanisms may affect responses to inhalant aeroallergens. The mechanisms proposed to explain the allergy-modulatory effect of geohelminths include the induction of regulatory T cells and the creation of an immunosuppressive environment in relevant tissues. New treatments being considered for the treatment of asthma include live infections with hookworms. Insights provided by how geohelminths modulate inflammatory responses may allow the development of new treatments that mimic these effects.

Idioma originalInglés
Páginas (desde-hasta)1031-1035
Número de páginas5
PublicaciónInternational Journal of Biochemistry and Cell Biology
EstadoPublicada - 2006
Publicado de forma externa


Profundice en los temas de investigación de 'Geohelminth infections: Impact on allergic diseases'. En conjunto forman una huella única.

Citar esto