From the configurational preference of dihydroceramide desaturase-1 towards Δ6-unsaturated substrates to the discovery of a new inhibitor

Ana Pou; José Luís Abad; Yadira F. Ordóñez; Maria Garrido; Josefina Casas; Gemma Fabriàs; Antonio Delgado

doi:10.1039/c6cc08268h

From the configurational preference of dihydroceramide desaturase-1 towards Δ⁶-unsaturated substrates to the discovery of a new inhibitor

Ana Pou, José Luís Abad, Yadira F. Ordóñez, Maria Garrido, Josefina Casas, Gemma Fabriàs, Antonio Delgado

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

6 Citas (Scopus)

Resumen

Dihydroceramide desaturase 1 (Des1) catalyzes the last step of ceramide synthesis de novo, thus regulating the physiologically relevant balance between dihydrosphingolipids and sphingolipids. Here we report on the configurational preference of Des1 towards isomeric Δ⁶-unsaturated dihydroceramide analogs and the discovery of a potent Des1 inhibitor.

Idioma original	Inglés
Páginas (desde-hasta)	4394-4397
Número de páginas	4
Publicación	Chemical Communications
Volumen	53
N.º	31
DOI	https://doi.org/10.1039/c6cc08268h
Estado	Publicada - 2017
Publicado de forma externa	Sí

Nota bibliográfica

Publisher Copyright:
© The Royal Society of Chemistry.

Financiación

Financiadores	Número del financiador
Spanish Ministry of Economy and Competitiveness	CTQ2014-54743, BES-2012-056019
Consejo Superior de Investigaciones Científicas

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10.1039/c6cc08268h

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AU - Garrido, Maria

AU - Casas, Josefina

AU - Fabriàs, Gemma

AU - Delgado, Antonio

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