Evaluation of a Non-Enzymatic Electrochemical Sensor Based on Co(OH)2-Functionalized Carbon Nanotubes for Glucose Detection

Diego Bolaños-Mendez; Lenys Fernández; Rafael Uribe; Alisson Cunalata-Castro; Gema González; Isamara Rojas; Andrés Chico-Proano; Alexis Debut; Luis Alberto Celi; Patricio Espinoza-Montero

doi:10.3390/s24237707

Evaluation of a Non-Enzymatic Electrochemical Sensor Based on Co(OH)₂-Functionalized Carbon Nanotubes for Glucose Detection

Diego Bolaños-Mendez, Lenys Fernández^*, Rafael Uribe, Alisson Cunalata-Castro, Gema González, Isamara Rojas, Andrés Chico-Proano, Alexis Debut, Luis Alberto Celi, Patricio Espinoza-Montero^*

^*Autor correspondiente de este trabajo

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

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Resumen

This work reports on the assessment of a non-hydrolytic electrochemical sensor for glucose sensing that is developed using functionalized carbon nanotubes (fCNTs)/Co(OH)₂. The morphology of the nanocomposite was investigated by scanning electron microscopy, which revealed that the CNTs interacted with Co(OH)₂. This content formed a nanocomposite that improved the electrochemical characterizations of the electrode, including the electrochemical active surface area and capacitance, thus improving sensitivity to glucose. In the electrochemical characterization by cyclic voltammetry and chronoamperometry, the increase in catalytic activity by Co(OH)₂ improved the stability and reproducibility of the glucose sensor without the use of enzymes, and its concentration range was between 50 and 700 μmol L⁻¹. The sensor exhibited good linearity towards glucose with LOD value of 43.200 µmol L⁻¹, which proved that the Co(OH)₂-fCNTs composite is judicious for constructing cost effective and feasible sensor for glucose detection.

Idioma original	Inglés
Número de artículo	7707
Publicación	Sensors
Volumen	24
N.º	23
DOI	https://doi.org/10.3390/s24237707
Estado	Publicada - dic. 2024

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Publisher Copyright:
© 2024 by the authors.

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Financiadores	Número del financiador
National Polytechnic School Department of Chemical Engineering, Quito

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title = "Evaluation of a Non-Enzymatic Electrochemical Sensor Based on Co(OH)2-Functionalized Carbon Nanotubes for Glucose Detection",

abstract = "This work reports on the assessment of a non-hydrolytic electrochemical sensor for glucose sensing that is developed using functionalized carbon nanotubes (fCNTs)/Co(OH)2. The morphology of the nanocomposite was investigated by scanning electron microscopy, which revealed that the CNTs interacted with Co(OH)2. This content formed a nanocomposite that improved the electrochemical characterizations of the electrode, including the electrochemical active surface area and capacitance, thus improving sensitivity to glucose. In the electrochemical characterization by cyclic voltammetry and chronoamperometry, the increase in catalytic activity by Co(OH)2 improved the stability and reproducibility of the glucose sensor without the use of enzymes, and its concentration range was between 50 and 700 μmol L−1. The sensor exhibited good linearity towards glucose with LOD value of 43.200 µmol L−1, which proved that the Co(OH)2-fCNTs composite is judicious for constructing cost effective and feasible sensor for glucose detection.",

keywords = "carbon nanotubes, cobalt hydroxide, electrochemical sensors, glucose, non-enzymatic",

author = "Diego Bola{\~n}os-Mendez and Lenys Fern{\'a}ndez and Rafael Uribe and Alisson Cunalata-Castro and Gema Gonz{\'a}lez and Isamara Rojas and Andr{\'e}s Chico-Proano and Alexis Debut and Celi, {Luis Alberto} and Patricio Espinoza-Montero",

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month = dec,

doi = "10.3390/s24237707",

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AU - Bolaños-Mendez, Diego

AU - Fernández, Lenys

AU - Uribe, Rafael

AU - Cunalata-Castro, Alisson

AU - González, Gema

AU - Rojas, Isamara

AU - Chico-Proano, Andrés

AU - Debut, Alexis

AU - Celi, Luis Alberto

AU - Espinoza-Montero, Patricio

PY - 2024/12

Y1 - 2024/12

N2 - This work reports on the assessment of a non-hydrolytic electrochemical sensor for glucose sensing that is developed using functionalized carbon nanotubes (fCNTs)/Co(OH)2. The morphology of the nanocomposite was investigated by scanning electron microscopy, which revealed that the CNTs interacted with Co(OH)2. This content formed a nanocomposite that improved the electrochemical characterizations of the electrode, including the electrochemical active surface area and capacitance, thus improving sensitivity to glucose. In the electrochemical characterization by cyclic voltammetry and chronoamperometry, the increase in catalytic activity by Co(OH)2 improved the stability and reproducibility of the glucose sensor without the use of enzymes, and its concentration range was between 50 and 700 μmol L−1. The sensor exhibited good linearity towards glucose with LOD value of 43.200 µmol L−1, which proved that the Co(OH)2-fCNTs composite is judicious for constructing cost effective and feasible sensor for glucose detection.

AB - This work reports on the assessment of a non-hydrolytic electrochemical sensor for glucose sensing that is developed using functionalized carbon nanotubes (fCNTs)/Co(OH)2. The morphology of the nanocomposite was investigated by scanning electron microscopy, which revealed that the CNTs interacted with Co(OH)2. This content formed a nanocomposite that improved the electrochemical characterizations of the electrode, including the electrochemical active surface area and capacitance, thus improving sensitivity to glucose. In the electrochemical characterization by cyclic voltammetry and chronoamperometry, the increase in catalytic activity by Co(OH)2 improved the stability and reproducibility of the glucose sensor without the use of enzymes, and its concentration range was between 50 and 700 μmol L−1. The sensor exhibited good linearity towards glucose with LOD value of 43.200 µmol L−1, which proved that the Co(OH)2-fCNTs composite is judicious for constructing cost effective and feasible sensor for glucose detection.

KW - carbon nanotubes

KW - cobalt hydroxide

KW - electrochemical sensors

KW - glucose

KW - non-enzymatic

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