Adaptive cell invasion maintains lateral line organ homeostasis in response to environmental changes

Julia Peloggia, Daniela Münch, Paloma Meneses-Giles, Andrés Romero-Carvajal, Mark E. Lush, Nathan D. Lawson, Melainia McClain, Y. Albert Pan, Tatjana Piotrowski

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

11 Citas (Scopus)

Resumen

Mammalian inner ear and fish lateral line sensory hair cells (HCs) detect fluid motion to transduce environmental signals. Actively maintained ionic homeostasis of the mammalian inner ear endolymph is essential for HC function. In contrast, fish lateral line HCs are exposed to the fluctuating ionic composition of the aqueous environment. Using lineage labeling, in vivo time-lapse imaging and scRNA-seq, we discovered highly motile skin-derived cells that invade mature mechanosensory organs of the zebrafish lateral line and differentiate into Neuromast-associated (Nm) ionocytes. This invasion is adaptive as it is triggered by environmental fluctuations. Our discovery of Nm ionocytes challenges the notion of an entirely placodally derived lateral line and identifies Nm ionocytes as likely regulators of HC function possibly by modulating the ionic microenvironment. Nm ionocytes provide an experimentally accessible in vivo system to study cell invasion and migration, as well as the physiological adaptation of vertebrate organs to changing environmental conditions.

Idioma originalInglés
Páginas (desde-hasta)1296-1312.e7
PublicaciónDevelopmental Cell
Volumen56
N.º9
DOI
EstadoPublicada - 3 may. 2021

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© 2021 Elsevier Inc.

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