A multi center comparative study of impulse control disorder in Latin American patients with Parkinson disease

Carolina Candelaria Ramírez Gómez, Marcos Serrano Dueñas, Oscar Bernal, Natalia Araoz, Michel Sáenz Farret, Victoria Aldinio, Verónica Montilla, Federico Micheli

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

24 Citas (Scopus)

Resumen

Objectives: Impulse control disorder (ICD) is a common adverse effect in patients with Parkinson disease who receive dopamine agonists; however, other factors are involved in itsmanifestations. To study the frequency and factors involved in the development of this adverse effect in a Latin American population, we conducted a cross-sectional multicenter study. Methods: Two hundred fifty-five patients in 3 Latin American centers were evaluated by examination and application of scales (Unified Parkinson's Disease Rating Scale, Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale, Hoehn and Yahr, Clinical Impression of Severity Index for Parkinson's Disease). Results: Of the patients, 27.4% had ICD, most of whom were on dopamine agonists. Other associated risk factors included a younger age at onset of Parkinson disease, moderate symptoms, a shorter evolution of the clinical manifestations, rapid eye movement (REM) sleep disorder behavior, and the consumption of tea, mate, and alcohol. Conclusions: The frequency of ICD is higher in Latin America than in Anglo-Saxon populations. Consuming tea and mate, in addition to the use of dopamine agonists, is a factor that may demonstrate a genetic link that predisposes patients to the establishment of an ICD.

Idioma originalInglés
Páginas (desde-hasta)51-55
Número de páginas5
PublicaciónClinical Neuropharmacology
Volumen40
N.º2
DOI
EstadoPublicada - 2017

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