TIME TO DEVELOP CHRONIC KIDNEY DISEASE IN AN ECUADORIAN TYPE 2 DIABETES MELLITUS COHORT: SURVIVAL ANALYSIS IN PRIMARY CARE: Survival analysis in primary care

Felipe Carrasco-Tenezaca; Francisco Barrera-Guarderas; Katherine De la Torre-Cisneros; Miguel Medina-Escudero; Oscar Venegas-Baca

doi:10.1016/j.jdiacomp.2021.108108

TIME TO DEVELOP CHRONIC KIDNEY DISEASE IN AN ECUADORIAN TYPE 2 DIABETES MELLITUS COHORT: SURVIVAL ANALYSIS IN PRIMARY CARE: Survival analysis in primary care

Felipe Carrasco-Tenezaca^*, Francisco Barrera-Guarderas, Katherine De la Torre-Cisneros, Miguel Medina-Escudero, Oscar Venegas-Baca

^*Corresponding author for this work

Faculty of Medicine

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Chronic Kidney Disease (CKD) represents a high burden to health systems. However, the survival time for CKD in a Type 2 Diabetes Mellitus (T2DM) population is unknown. Aims: Determine the risk factors, survival time and the incidence rate of CKD in T2DM. Methods: Retrospective clinical cohort study (follow up 10 years). 513 patients with T2DM were included. Numerical variables were compared using the mean difference. Chi squared and odds ratios were calculated for categorical variables. Survival analysis was done through life tables and Kaplan-Meier. Results: The mean difference between the group that developed CKD and those who did not, was significant in: age, age at diagnosis of T2DM and years with T2DM. Risk factors for developing CKD were: the presence of hypertension, albuminuria, retinopathy, high triglycerides and high HbA1c. The incidence rate was 32.07 per 1000 person-years of follow-up and 207 (40.4%) of patients developed CKD during the study. The median for developing CKD was 20.52 years of disease with an increasing risk with time. Conclusions: Half of the patients with T2DM will develop CKD by the second decade of disease. Time, arterial hypertension, retinopathy, albuminuria and triglycerides are factors associated with CKD in patients with T2DM.

Original language	English
Article number	108108
Journal	Journal of Diabetes and its Complications
Volume	36
Issue number	2
DOIs	https://doi.org/10.1016/j.jdiacomp.2021.108108
State	Published - 22 Dec 2021

Bibliographical note

Publisher Copyright:
© 2021 Elsevier Inc.

Funding

The authors thank the staff and the patients of Chimbacalle Medical Centre for their valuable contributions and trust through all these years. The authors have not received specific grant or not been founded from any agency or institution for this work. Research idea and study design: F.B.G. K.T.C. F.C.T. M.E.M. O.V.B.; data acquisition: F.B.G. F.C.T. M.E.M. O.V.B.; data analysis/interpretation: F.B.G. K.T.C. F.C.T.; statistical analysis: F.B.G. K.T.C. F.C.T. Each author contributed important intellectual content during manuscript drafting or revision and accepts accountability for the overall work by ensuring that questions pertaining to the accuracy or integrity of any portion of the work are appropriately investigated and resolved.

Keywords

Diabetes complications
Diabetic nephropathy
Primary care
Survival analysis
Type 2 Diabetes Mellitus

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jdiacomp.2021.108108

Cite this

Carrasco-Tenezaca, F., Barrera-Guarderas, F., De la Torre-Cisneros, K., Medina-Escudero, M., & Venegas-Baca, O. (2021). TIME TO DEVELOP CHRONIC KIDNEY DISEASE IN AN ECUADORIAN TYPE 2 DIABETES MELLITUS COHORT: SURVIVAL ANALYSIS IN PRIMARY CARE: Survival analysis in primary care. Journal of Diabetes and its Complications, 36(2), Article 108108. https://doi.org/10.1016/j.jdiacomp.2021.108108

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title = "TIME TO DEVELOP CHRONIC KIDNEY DISEASE IN AN ECUADORIAN TYPE 2 DIABETES MELLITUS COHORT: SURVIVAL ANALYSIS IN PRIMARY CARE: Survival analysis in primary care",

abstract = "Chronic Kidney Disease (CKD) represents a high burden to health systems. However, the survival time for CKD in a Type 2 Diabetes Mellitus (T2DM) population is unknown. Aims: Determine the risk factors, survival time and the incidence rate of CKD in T2DM. Methods: Retrospective clinical cohort study (follow up 10 years). 513 patients with T2DM were included. Numerical variables were compared using the mean difference. Chi squared and odds ratios were calculated for categorical variables. Survival analysis was done through life tables and Kaplan-Meier. Results: The mean difference between the group that developed CKD and those who did not, was significant in: age, age at diagnosis of T2DM and years with T2DM. Risk factors for developing CKD were: the presence of hypertension, albuminuria, retinopathy, high triglycerides and high HbA1c. The incidence rate was 32.07 per 1000 person-years of follow-up and 207 (40.4%) of patients developed CKD during the study. The median for developing CKD was 20.52 years of disease with an increasing risk with time. Conclusions: Half of the patients with T2DM will develop CKD by the second decade of disease. Time, arterial hypertension, retinopathy, albuminuria and triglycerides are factors associated with CKD in patients with T2DM.",

keywords = "Diabetes complications, Diabetic nephropathy, Primary care, Survival analysis, Type 2 Diabetes Mellitus",

author = "Felipe Carrasco-Tenezaca and Francisco Barrera-Guarderas and {De la Torre-Cisneros}, Katherine and Miguel Medina-Escudero and Oscar Venegas-Baca",

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year = "2021",

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doi = "10.1016/j.jdiacomp.2021.108108",

language = "English",

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Carrasco-Tenezaca, F, Barrera-Guarderas, F, De la Torre-Cisneros, K, Medina-Escudero, M & Venegas-Baca, O 2021, 'TIME TO DEVELOP CHRONIC KIDNEY DISEASE IN AN ECUADORIAN TYPE 2 DIABETES MELLITUS COHORT: SURVIVAL ANALYSIS IN PRIMARY CARE: Survival analysis in primary care', Journal of Diabetes and its Complications, vol. 36, no. 2, 108108. https://doi.org/10.1016/j.jdiacomp.2021.108108

TIME TO DEVELOP CHRONIC KIDNEY DISEASE IN AN ECUADORIAN TYPE 2 DIABETES MELLITUS COHORT: SURVIVAL ANALYSIS IN PRIMARY CARE: Survival analysis in primary care. / Carrasco-Tenezaca, Felipe; Barrera-Guarderas, Francisco; De la Torre-Cisneros, Katherine et al.
In: Journal of Diabetes and its Complications, Vol. 36, No. 2, 108108, 22.12.2021.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - TIME TO DEVELOP CHRONIC KIDNEY DISEASE IN AN ECUADORIAN TYPE 2 DIABETES MELLITUS COHORT: SURVIVAL ANALYSIS IN PRIMARY CARE

T2 - Survival analysis in primary care

AU - Carrasco-Tenezaca, Felipe

AU - Barrera-Guarderas, Francisco

AU - De la Torre-Cisneros, Katherine

AU - Medina-Escudero, Miguel

AU - Venegas-Baca, Oscar

PY - 2021/12/22

Y1 - 2021/12/22

N2 - Chronic Kidney Disease (CKD) represents a high burden to health systems. However, the survival time for CKD in a Type 2 Diabetes Mellitus (T2DM) population is unknown. Aims: Determine the risk factors, survival time and the incidence rate of CKD in T2DM. Methods: Retrospective clinical cohort study (follow up 10 years). 513 patients with T2DM were included. Numerical variables were compared using the mean difference. Chi squared and odds ratios were calculated for categorical variables. Survival analysis was done through life tables and Kaplan-Meier. Results: The mean difference between the group that developed CKD and those who did not, was significant in: age, age at diagnosis of T2DM and years with T2DM. Risk factors for developing CKD were: the presence of hypertension, albuminuria, retinopathy, high triglycerides and high HbA1c. The incidence rate was 32.07 per 1000 person-years of follow-up and 207 (40.4%) of patients developed CKD during the study. The median for developing CKD was 20.52 years of disease with an increasing risk with time. Conclusions: Half of the patients with T2DM will develop CKD by the second decade of disease. Time, arterial hypertension, retinopathy, albuminuria and triglycerides are factors associated with CKD in patients with T2DM.

AB - Chronic Kidney Disease (CKD) represents a high burden to health systems. However, the survival time for CKD in a Type 2 Diabetes Mellitus (T2DM) population is unknown. Aims: Determine the risk factors, survival time and the incidence rate of CKD in T2DM. Methods: Retrospective clinical cohort study (follow up 10 years). 513 patients with T2DM were included. Numerical variables were compared using the mean difference. Chi squared and odds ratios were calculated for categorical variables. Survival analysis was done through life tables and Kaplan-Meier. Results: The mean difference between the group that developed CKD and those who did not, was significant in: age, age at diagnosis of T2DM and years with T2DM. Risk factors for developing CKD were: the presence of hypertension, albuminuria, retinopathy, high triglycerides and high HbA1c. The incidence rate was 32.07 per 1000 person-years of follow-up and 207 (40.4%) of patients developed CKD during the study. The median for developing CKD was 20.52 years of disease with an increasing risk with time. Conclusions: Half of the patients with T2DM will develop CKD by the second decade of disease. Time, arterial hypertension, retinopathy, albuminuria and triglycerides are factors associated with CKD in patients with T2DM.

KW - Diabetes complications

KW - Diabetic nephropathy

KW - Primary care

KW - Survival analysis

KW - Type 2 Diabetes Mellitus

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U2 - 10.1016/j.jdiacomp.2021.108108

DO - 10.1016/j.jdiacomp.2021.108108

M3 - Article

C2 - 34965908

AN - SCOPUS:85121977611

SN - 1056-8727

VL - 36

JO - Journal of Diabetes and its Complications

JF - Journal of Diabetes and its Complications

IS - 2

M1 - 108108

ER -

TIME TO DEVELOP CHRONIC KIDNEY DISEASE IN AN ECUADORIAN TYPE 2 DIABETES MELLITUS COHORT: SURVIVAL ANALYSIS IN PRIMARY CARE: Survival analysis in primary care

Abstract

Bibliographical note

Funding

Keywords

UN SDGs

Access to Document

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