Repeated treatments with albendazole enhance Th2 responses to Ascaris lumbricoides, but not to aeroallergens, in children from rural communities in the tropics

Philip J. Cooper; Ana Lucia Moncayo; Irene Guadalupe; Susana Benitez; Maritza Vaca; Martha Chico; George E. Griffin

doi:10.1086/591945

Repeated treatments with albendazole enhance Th2 responses to Ascaris lumbricoides, but not to aeroallergens, in children from rural communities in the tropics

Philip J. Cooper, Ana Lucia Moncayo, Irene Guadalupe, Susana Benitez, Maritza Vaca, Martha Chico, George E. Griffin

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Geohelminth infections are associated with modulation of immunity to parasite antigens and aeroallergens. To investigate the possibility that this modulation is affected by anthelmintic treatment, we compared cytokine responses in children who were treated with repeated doses of albendazole over 1 year versus those in children who had were not treated. Whole-blood samples were cultured with Ascaris antigen and house dust mite and cockroach allergens, and levels of interleukin (IL)-5, IL-13, interferon-γ, and IL-10 were measured. Anthelmintic treatment was associated with enhanced production of Th2cytokines in response to parasite antigen but did not affect responses to aeroallergens. The data indicate that long-term treatment may be associated with increased Th2 antiparasite immunity.

Original language	English
Pages (from-to)	1237-1242
Number of pages	6
Journal	Journal of Infectious Diseases
Volume	198
Issue number	8
DOIs	https://doi.org/10.1086/591945
State	Published - 15 Oct 2008
Externally published	Yes

Funding

Received 5 February 2008; accepted 24 April 2008; electronically published XX August 2008. Potential conflicts of interest: none reported. Financial support: Wellcome Trust (grant 060120/Z/99/C to P.J.C.). Reprints or correspondence: Dr. Philip Cooper, Casilla 17-14-39, Carcelen, Quito, Ecuador ([email protected]).

Funders	Funder number
Wellcome Trust	060120/Z/99/C

Access to Document

10.1086/591945

Cite this

@article{c4f72f7b8a1341f795e849dcd15f7bf9,

title = "Repeated treatments with albendazole enhance Th2 responses to Ascaris lumbricoides, but not to aeroallergens, in children from rural communities in the tropics",

abstract = "Geohelminth infections are associated with modulation of immunity to parasite antigens and aeroallergens. To investigate the possibility that this modulation is affected by anthelmintic treatment, we compared cytokine responses in children who were treated with repeated doses of albendazole over 1 year versus those in children who had were not treated. Whole-blood samples were cultured with Ascaris antigen and house dust mite and cockroach allergens, and levels of interleukin (IL)-5, IL-13, interferon-γ, and IL-10 were measured. Anthelmintic treatment was associated with enhanced production of Th2cytokines in response to parasite antigen but did not affect responses to aeroallergens. The data indicate that long-term treatment may be associated with increased Th2 antiparasite immunity.",

author = "Cooper, {Philip J.} and Moncayo, {Ana Lucia} and Irene Guadalupe and Susana Benitez and Maritza Vaca and Martha Chico and Griffin, {George E.}",

year = "2008",

month = oct,

day = "15",

doi = "10.1086/591945",

language = "English",

volume = "198",

pages = "1237--1242",

journal = "Journal of Infectious Diseases",

issn = "0022-1899",

publisher = "Oxford University Press",

number = "8",

}

Repeated treatments with albendazole enhance Th2 responses to Ascaris lumbricoides, but not to aeroallergens, in children from rural communities in the tropics. / Cooper, Philip J.; Moncayo, Ana Lucia; Guadalupe, Irene et al.
In: Journal of Infectious Diseases, Vol. 198, No. 8, 15.10.2008, p. 1237-1242.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Repeated treatments with albendazole enhance Th2 responses to Ascaris lumbricoides, but not to aeroallergens, in children from rural communities in the tropics

AU - Cooper, Philip J.

AU - Moncayo, Ana Lucia

AU - Guadalupe, Irene

AU - Benitez, Susana

AU - Vaca, Maritza

AU - Chico, Martha

AU - Griffin, George E.

PY - 2008/10/15

Y1 - 2008/10/15

N2 - Geohelminth infections are associated with modulation of immunity to parasite antigens and aeroallergens. To investigate the possibility that this modulation is affected by anthelmintic treatment, we compared cytokine responses in children who were treated with repeated doses of albendazole over 1 year versus those in children who had were not treated. Whole-blood samples were cultured with Ascaris antigen and house dust mite and cockroach allergens, and levels of interleukin (IL)-5, IL-13, interferon-γ, and IL-10 were measured. Anthelmintic treatment was associated with enhanced production of Th2cytokines in response to parasite antigen but did not affect responses to aeroallergens. The data indicate that long-term treatment may be associated with increased Th2 antiparasite immunity.

AB - Geohelminth infections are associated with modulation of immunity to parasite antigens and aeroallergens. To investigate the possibility that this modulation is affected by anthelmintic treatment, we compared cytokine responses in children who were treated with repeated doses of albendazole over 1 year versus those in children who had were not treated. Whole-blood samples were cultured with Ascaris antigen and house dust mite and cockroach allergens, and levels of interleukin (IL)-5, IL-13, interferon-γ, and IL-10 were measured. Anthelmintic treatment was associated with enhanced production of Th2cytokines in response to parasite antigen but did not affect responses to aeroallergens. The data indicate that long-term treatment may be associated with increased Th2 antiparasite immunity.

UR - http://www.scopus.com/inward/record.url?scp=54749147823&partnerID=8YFLogxK

U2 - 10.1086/591945

DO - 10.1086/591945

M3 - Article

C2 - 18729781

AN - SCOPUS:54749147823

SN - 0022-1899

VL - 198

SP - 1237

EP - 1242

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 8

ER -

Repeated treatments with albendazole enhance Th2 responses to Ascaris lumbricoides, but not to aeroallergens, in children from rural communities in the tropics

Abstract

Funding

Access to Document

Other files and links

Fingerprint

Cite this