Repeated treatments with albendazole enhance Th2 responses to Ascaris lumbricoides, but not to aeroallergens, in children from rural communities in the tropics

Philip J. Cooper, Ana Lucia Moncayo, Irene Guadalupe, Susana Benitez, Maritza Vaca, Martha Chico, George E. Griffin

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Geohelminth infections are associated with modulation of immunity to parasite antigens and aeroallergens. To investigate the possibility that this modulation is affected by anthelmintic treatment, we compared cytokine responses in children who were treated with repeated doses of albendazole over 1 year versus those in children who had were not treated. Whole-blood samples were cultured with Ascaris antigen and house dust mite and cockroach allergens, and levels of interleukin (IL)-5, IL-13, interferon-γ, and IL-10 were measured. Anthelmintic treatment was associated with enhanced production of Th2cytokines in response to parasite antigen but did not affect responses to aeroallergens. The data indicate that long-term treatment may be associated with increased Th2 antiparasite immunity.

Original languageEnglish
Pages (from-to)1237-1242
Number of pages6
JournalJournal of Infectious Diseases
Volume198
Issue number8
DOIs
StatePublished - 15 Oct 2008
Externally publishedYes

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