From the configurational preference of dihydroceramide desaturase-1 towards Δ6-unsaturated substrates to the discovery of a new inhibitor

Ana Pou; José Luís Abad; Yadira F. Ordóñez; Maria Garrido; Josefina Casas; Gemma Fabriàs; Antonio Delgado

doi:10.1039/c6cc08268h

From the configurational preference of dihydroceramide desaturase-1 towards Δ⁶-unsaturated substrates to the discovery of a new inhibitor

Ana Pou, José Luís Abad, Yadira F. Ordóñez, Maria Garrido, Josefina Casas, Gemma Fabriàs^*, Antonio Delgado

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Dihydroceramide desaturase 1 (Des1) catalyzes the last step of ceramide synthesis de novo, thus regulating the physiologically relevant balance between dihydrosphingolipids and sphingolipids. Here we report on the configurational preference of Des1 towards isomeric Δ⁶-unsaturated dihydroceramide analogs and the discovery of a potent Des1 inhibitor.

Original language	English
Pages (from-to)	4394-4397
Number of pages	4
Journal	Chemical Communications
Volume	53
Issue number	31
DOIs	https://doi.org/10.1039/c6cc08268h
State	Published - 2017
Externally published	Yes

Bibliographical note

Publisher Copyright:
© The Royal Society of Chemistry.

Funding

This work was partially supported by the Spanish Ministry of Economy and Competitiveness through Grant CTQ2014-54743- R. Predoctoral fellowships from the Spanish Ministry of Economy and Competitiveness (BES-2012-056019, to A. P.), CSIC (to M. G.) and SENESCYT-Ecuador (to Y. F. O.) are also acknowledged.

Funders	Funder number
Spanish Ministry of Economy and Competitiveness	CTQ2014-54743, BES-2012-056019
Consejo Superior de Investigaciones Científicas

Access to Document

10.1039/c6cc08268h

Cite this

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AU - Fabriàs, Gemma

AU - Delgado, Antonio

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