TY - JOUR
T1 - Comparative Efficacy of Percutaneous Coronary Intervention Versus Coronary Artery Bypass Grafting in the Treatment of Ischemic Heart Disease
T2 - A Systematic Review and Meta-Analysis of Recent Randomized Controlled Trials
AU - Llerena-Velastegui, Jordan
AU - Zumbana-Podaneva, Kristina
AU - Velastegui-Zurita, Sebastian
AU - Mejia-Mora, Melany
AU - Perez-Tomassetti, Juan
AU - Cabrera-Cruz, Allison
AU - Haro-Arteaga, Pablo
AU - de Jesus, Ana Clara Fonseca Souza
AU - Coelho, Pedro Moraes
AU - Sanahuja-Montiel, Cristian
N1 - Publisher Copyright:
© Journal compilation
PY - 2024
Y1 - 2024
N2 - Background: Ischemic heart disease (IHD) is a major global health issue and a leading cause of death. This study compares the effectiveness of percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) in the management of IHD, focusing on their impact on revascularization, myocardial infarction (MI), and post-procedural stroke. This study aimed to evaluate and compare the effectiveness of PCI and CABG in treating IHD based on an exhaustive literature review of the past 5 years, emphasizing recent advancements and outcomes in IHD management. Methods: A comprehensive literature review analyzed 32 randomized controlled trials (RCTs) retrieved from databases such as PubMed, Cochrane Library, and Google Scholar. The study specifically assessed the incidences of revascularization, stroke, and MI in patients treated with either PCI or CABG. The comparison between CABG and PCI exclusively focused on lesions with a SYNTAX score exceeding 32. Results: Our findings highlight CABG’s significant efficacy over PCI in reducing revascularization and MI. The aggregated Mantel-Haenszel (M-H) value for revascularization was 1.85 (95% confidence interval (CI): 1.65 - 2.07), signifying CABG’s advantage. Additionally, CABG demonstrated superior performance in diminishing MI occurrences (M-H = 2.71, 95% CI: 1.13 - 6.53). In contrast, PCI was more effective in reducing stroke (M-H = 0.80, 95% CI: 0.60 - 1.10). Conclusion: The study confirms CABG’s superiority in reducing revascularization and MI in IHD patients, highlighting PCI’s effectiveness in reducing stroke risk. These findings underscore the importance of personalized treatment strategies in IHD management and emphasize the need for ongoing research and evidence-based guidelines to aid in treatment selection for IHD patients.
AB - Background: Ischemic heart disease (IHD) is a major global health issue and a leading cause of death. This study compares the effectiveness of percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) in the management of IHD, focusing on their impact on revascularization, myocardial infarction (MI), and post-procedural stroke. This study aimed to evaluate and compare the effectiveness of PCI and CABG in treating IHD based on an exhaustive literature review of the past 5 years, emphasizing recent advancements and outcomes in IHD management. Methods: A comprehensive literature review analyzed 32 randomized controlled trials (RCTs) retrieved from databases such as PubMed, Cochrane Library, and Google Scholar. The study specifically assessed the incidences of revascularization, stroke, and MI in patients treated with either PCI or CABG. The comparison between CABG and PCI exclusively focused on lesions with a SYNTAX score exceeding 32. Results: Our findings highlight CABG’s significant efficacy over PCI in reducing revascularization and MI. The aggregated Mantel-Haenszel (M-H) value for revascularization was 1.85 (95% confidence interval (CI): 1.65 - 2.07), signifying CABG’s advantage. Additionally, CABG demonstrated superior performance in diminishing MI occurrences (M-H = 2.71, 95% CI: 1.13 - 6.53). In contrast, PCI was more effective in reducing stroke (M-H = 0.80, 95% CI: 0.60 - 1.10). Conclusion: The study confirms CABG’s superiority in reducing revascularization and MI in IHD patients, highlighting PCI’s effectiveness in reducing stroke risk. These findings underscore the importance of personalized treatment strategies in IHD management and emphasize the need for ongoing research and evidence-based guidelines to aid in treatment selection for IHD patients.
KW - Coronary artery bypass graft surgery
KW - Ischemic heart disease
KW - Meta-analysis
KW - Percutaneous coronary intervention
KW - Revascularization
UR - http://www.scopus.com/inward/record.url?scp=85199278630&partnerID=8YFLogxK
U2 - 10.14740/cr1638
DO - 10.14740/cr1638
M3 - Article
AN - SCOPUS:85199278630
SN - 1923-2829
VL - 15
SP - 153
EP - 168
JO - Cardiology Research
JF - Cardiology Research
IS - 3
ER -